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Obesity can affect the pathogenesis of OA through biomechanical

effects as well as via increased metainflammation (metabolic inflammation). Increased obesity is associated with higher levels of joint loading and reduced levels of physical activity, which in turn reduces muscle strength. Combined, these effects can result in the structural changes of OA. Structural disease results in pain, which presents a barrier to physical activity, further reducing energy expenditure and resulting in reduced muscle mass and increased fat mass. Thus, these factors may contribute to a vicious cycle of obesity and OA...Read more

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