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PRP is a concentration of blood platelets and growth factors obtained from the patient’s own blood using centrifugation techniques can be utilized immediately for clinical use. They contribute to the regulation of homeostasis and promote wound repair. In the plasma, numerous proteins are contained, such as insulin-like growth factor IGF, platelet-derived growth factor (PDGF), platelet factor interleukin (IL), platelet-derived angiogenesis factor (PDAF), epidermal growth factor (EGF), transforming growth factor (TGF), vascular endothelial growth factor (VEGF), and fibronectin (Lubkowska, 2012). Such anabolic growth factors inhibit inflammation and pain, as well as enhance the cartilage and bone matrix biosynthesis (Brandl, 2010)...Read more
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Obesity can affect the pathogenesis of OA through biomechanical
effects as well as via increased metainflammation (metabolic inflammation). Increased obesity is associated with higher levels of joint loading and reduced levels of physical activity, which in turn reduces muscle strength. Combined, these effects can result in the structural changes of OA. Structural disease results in pain, which presents a barrier to physical activity, further reducing energy expenditure and resulting in reduced muscle mass and increased fat mass. Thus, these factors may contribute to a vicious cycle of obesity and OA...Read more
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