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Obesity can affect the pathogenesis of OA through biomechanical

effects as well as via increased metainflammation (metabolic

inflammation). Increased obesity is associated with higher levels of joint

loading and reduced levels of physical activity, which in turn reduces

muscle strength. Combined, these effects can result in the structural

changes of OA. Structural disease results in pain, which presents a

barrier to physical activity, further reducing energy expenditure and

resulting in reduced muscle mass and increased fat mass. Thus, these

factors may contribute to a vicious cycle of obesity and OA...Read more

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